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Alternatively, due to the presence of biotin on the closed SpyLock, we are able to couple with excess of antibody, drive the reaction to completion and purify away any unreacted antibody monomers as well as antibody dimers

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Future studies should standardize methodological approaches across populations and increase sample sizes

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However, if the nausea or discomfort persists beyond a week, it is a clear sign to pause and reassess